A service-enabling framework for the session initiation protocol (SIP)

In this dissertation, we propose a framework to provide multimedia communication services. Our proposed framework is based on SIP (Session Initiation Protocol) and has four fundamental properties: it is available, secure, high performing, and oriented to innovations. The framework is not an architecture with a rigid structure. Instead, the framework is a toolkit made up of a set of tools that can be combined in different ways. The combination of these tools provides applications and services with functionality needed to implement a wide variety of multimedia communication services. Applications and services built on top of the framework use different tools within the toolkit in order to provide their desired overall functionality. The functionality provided by the framework includes a number of primitives to be used by applications and services. These primitives mostly relate to multiparty communications and include floor control. The framework also offers support functions that relate to PSTN (Public Switched Telephony Network) interworking, policy control, and consent-based communications. Additionally, the framework contains functions that relate to signalling transport, multihoming, mobility, security, and NAT (Network Address Translation) traversal. The framework also allows building overlay networks when a SIP network infrastructure is not available. In order to test and refine the ideas presented in this dissertation, we have implemented most of them in proof-of-concept prototypes. We have used experiments and simulations to validate our assumptions and obtain new insights

Signalling Transport Protocols

SCTP is a newly developed transport protocol tailored for signalling transport. Whereas in theory SCTP is supposed to achieve a much better performance than TCP and UDP, at present there are no experimental results showing SCTP s real benefits. This paper analyzes SCTP s strengths and weaknesses and provides simulation results. We implemented SIP on top of UDP, TCP and SCTP in the network simulator and compared the three transport protocols under different network conditions

Signalling Transport Protocols

SCTP is a newly developed transport protocol tailored for signalling transport. Whereas in theory SCTP is supposed to achieve a much better performance than TCP and UDP, at present there are no experimental results showing SCTP s real benefits. This paper analyzes SCTP s strengths and weaknesses and provides simulation results. We implemented SIP on top of UDP, TCP and SCTP in the network simulator and compared the three transport protocols under different network conditions

Analysis of Paired Primary-Metastatic Hormone-Receptor Positive Breast Tumors (HRPBC) Uncovers Potential Novel Drivers of Hormonal Resistance

We sought to identify genetic variants associated with disease relapse and failure to hormonal treatment in hormone-receptor positive breast cancer (HRPBC). We analyzed a series of HRPBC with distant relapse, by sequencing pairs (n = 11) of tumors (primary and metastases) at >800X. Comparative genomic hybridization was performed as well. Top hits, based on the frequency of alteration and severity of the changes, were tested in the TCGA series. Genes determining the most parsimonious prognostic signature were studied for their functional role in vitro, by performing cell growth assays in hormonal-deprivation conditions, a setting that mimics treatment with aromatase inhibitors. Severe alterations were recurrently found in 18 genes in the pairs. However, only MYC, DNAH5, CSFR1, EPHA7, ARID1B, and KMT2C preserved an independent prognosis impact and/or showed a significantly different incidence of alterations between relapsed and non-relapsed cases in the TCGA series. The signature composed of MYC, KMT2C, and EPHA7 best discriminated the clinical course, (overall survival 90,7 vs. 144,5 months; p = 0.0001). Having an alteration in any of the genes of the signature implied a hazard ratio of death of 3.25 (p<0.0001), and early relapse during the adjuvant hormonal treatment. The presence of the D348N mutation in KMT2C and/or the T666I mutation in the kinase domain of EPHA7 conferred hormonal resistance in vitro. Novel inactivating mutations in KMT2C and EPHA7, which confer hormonal resistance, are linked to adverse clinical course in HRPBC

The 3 G IP Multimedia Subsystem (IMS). : Merging the Internet and the Cellular Worlds.

West Sussexxv, 427 p, Fig, 25 cm

The 3 G IP Multimedia Subsystem (IMS). : Merging the Internet and the Cellular Worlds.

West Sussexxxvii, 427 p, 25 cm

IMS: The New Generation of Internet-Protocol-Based Multimedia Services

Legacy networks, both fixed and mobile, which were originally designed for voice communications, are progressively migrating to new infrastructures that promise to revolutionize the services offered. In this paper, we will cover this new generation of personal communication services, with an emphasis on the family of Internet protocol (IP)-based multimedia subsystem (IMS)-aided infrastructure that relies on the session initiation protocol (SIP). As a benefit, the end users will enjoy a new generation of personal communications services that are accessible anywhere and anytime. These services are timedia subsystem (IMS)-aided infrastructure that relies on the directly related to the end users rather than to their diverse devices. It is anticipated that the new deployments of next-of the IMS technology. generation networks (all-IP based) will accelerate the adoptio